A new study shows that a curcumin derivative may help treat chemo-resistant head and neck cancer.

If you’ve ever cooked or ordered Indian food, then you’re probably familiar with the spice turmeric. For years, turmeric’s active ingredient -- curcumin -- has been shown to have amazing health benefits. Now, researchers have found yet another one to add to the list: A new study shows that a curcumin derivative may help treat chemo-resistant head and neck cancer. Lead study author Thomas E. Carey, PhD, codirector of the Head and Neck Oncology Program at University of Michigan Comprehensive Cancer Center in Ann Arbor, had heard from colleagues that a curcumin compound made inroads in treating prostate cancer, so he and his colleagues composed their own study, which was published in the May 2011 edition of Archives of Otolaryngology -- Head and Neck Surgery. I called Dr. Carey because I was curious to know just how much this wonder spice could do -- and how, exactly, it works its magic in our bodies. THE CHEMO CONUNDRUM For unknown reasons, some patients with head and neck cancer do not respond well to chemotherapy -- their tumor cells become resistant to cisplatin, a platinum-based, highly toxic drug that is the typical first-line treatment for this type of cancer. As patients become resistant, doctors must increase the dosage of cisplatin, which increases the likelihood of serious and even debilitating side effects such as severe kidney impairment, painful urination, hearing loss, loss of balance, ringing in the ears, swelling in the feet or ankles, unusual tiredness and seizures. "It’s really hellish," said Dr. Carey.So he and his coauthors analyzed cells in vitro in a lab -- they tested tumor cell lines derived from head and neck cancer patients for naturally occurring chemo-resistance. Once they found chemo-resistant cancer cells, they split them into two groups and then tested a different treatment on each. In one group of cells, they tested a new chemo combination of cisplatin and a curcumin-based compound called FLLL 32, while the control group of cells was given the traditional chemo treatment of cisplatin alone. When analyzing the results from the group that got the combo chemo drug, researchers found that they were able to use four times less of the highly toxic cisplatin while still killing tumor cells just as effectively as a higher dose of cisplatin alone. How? The curcumin compound lowered the level of a protein called STAT3 that leads to chemo resistance. "In head and neck cancer, we don’t really understand why some tumors have high levels of the STAT3 protein and others don’t," said Dr. Carey. "But if we can create a drug out of this curcumin compound, we could use it along with cisplatin to make the chemotherapy more effective without adding toxicity or to make it equally effective and less toxic."WHAT THE FUTURE HOLDS Before he can celebrate too much, however, Dr. Carey has a lot of work ahead. For all its promise, the curcumin compound is not yet ready for human trials, because right now it’s poorly absorbed by the body. The team of chemists on the curcumin project are working to make the treatment soluble and more bioavailable. Then the next step will be to replicate the experiment "in vivo" by placing human cancer cells into mice with inactive immune systems and trying to achieve the same result with treatment involving curcumin. Past studies, according to Dr. Carey, have shown that eating a diet rich in curcumin (a diet rich in the turmeric spice) is associated with a lower risk of developing certain cancers. In other words, there’s a chance that curcumin may not just be useful as a treatment for head and neck cancer but also as a form of prevention, though that hasn’t yet been studied. What about taking curcumin supplements? Dr. Carey said to talk to your doctor first. "We don’t know if supplements would have similar effects," he said. But you may want to cook or order turmeric-rich foods, like Indian dishes. If nothing else, it’ll make your taste buds happy.Source(s): Thomas E. Carey, PhD, researcher, professor of otorhinolaryngology and pharmacology, University of Michigan Medical School, and codirector of the head and neck oncology program, University of Michigan Comprehensive Cancer Center, Ann Arbor.Be well, Carole Jackson Bottom Line's Daily Health NewsYou received this free E-letter because you have requested it. You are on the mailing list as enayetallah@msn.com. Or... a friend forwarded it to you. Click here to easily subscribe.You can easily unsubscribe by clicking here.To change your e-mail address click here.To update your e-mail preferences click here.Important: Help your friends live more healthfully -- forward this E-letter to them.Better: Send it to many friends and your whole family.This is a free e-mail service of BottomLineSecrets.com and Boardroom Inc.Need to contact us? Boardroom Inc. 281 Tresser Boulevard Stamford, CT 06901-3246 ATTN: Web TeamPrivacy Policy: BottomLinePublications.com Web Site Privacy PolicyRequired Disclaimer: The information provided herein should not be construed as a health-care diagnosis, treatment regimen or any other prescribed health-care advice or instruction. The information is provided with the understanding that the publisher is not engaged in the practice of medicine or any other health-care profession and does not enter into a health-care practitioner/patient relationship with its readers. The publisher does not advise or recommend to its readers treatment or action with regard to matters relating to their health or well-being other than to suggest that readers consult appropriate health-care professionals in such matters. No action should be taken based solely on the content of this publication. The information and opinions provided herein are believed to be accurate and sound at the time of publication, based on the best judgment available to the authors. However, readers who rely on information in this publication to replace the advice of health-care professionals, or who fail to consult with health-care professionals, assume all risks of such conduct. The publisher is not responsible for errors or omissions.Bottom Line's Daily Health News is a registered trademark of Boardroom, Inc.Copyright (c) 2011 by Boardroom Inc. 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